Reaction #495241

Reaction equation

Metformin hydrochloride

metformin hydrochloride

magnesium stearate

→

Metformin

Solvents

water

Conditions

Workup

1. 1
   Otherdried in the same device
2. 2
   OtherDried granulate
3. 3
   OtherObtained granulate
4. 4
   Otheris obtained

Procedure

Metformin hydrochloride is screened through 1 mm sieve. Screened metformin hydrochloride and hydroxypropylmethylcellulose are granulated in fluid bed granulator with demineralized water and dried in the same device. Dried granulate is screened through 1 mm sieve. Obtained granulate and microcrystalline cellulose are homogenously blended in a bin blender. Pre-sieved magnesium stearate is added to the obtained blend and blended in a bin blender so that the final blend is obtained.

Source