Reaction #487515

Reaction equation

Methyl (6-(Benzyloxy)purin-9-yl)acetate

NaOH

HCl

→

(6-(Benzyloxy)purin-9-yl)acetic acid

Solvents

methanol

Conditions

Workup

1. 1
   OtherThe precipitate was separated from the mixture by filtration
2. 2
   Washwashed with water and ether

Procedure

Methyl (6-(Benzyloxy)purin-9-yl)acetate (2.10 g; 7,0 mmol) was dissolved in methanol (70 ml) and 0.1 M NaOH (85 ml) is added. After 15 min. the pH of the reaction mixture was lowered by addition of 0.1 M HCl (˜80 ml) to pH 3. The precipitate was separated from the mixture by filtration and washed with water and ether. Yield: 1.80 g (90.2%). 1H-NMR (DMSO-d6): 8.55 (1H, s); 8.37 (1H, s); 7.55-7.30 (5H, m); 5.64 (2H, s); 5.09 (2H, s).

Source