Reaction #487499

Reaction equation

aniline

1,2-bis(diphenylphosphino)ethane

phenylazide

THF

→

Diphenylurea

Conditions

Workup

1. 1
   workup.ADDITIONwas pre-charged with [11C]CO
2. 2
   Otherwas flushed with N2 (the [11C]CO-
3. 3
   OtherA small amount of crude product was collected

Procedure

In a capped vial (1 mL) containing a solution of phenylazide (6.6 mg, 55 μmol) in dry THF (300 μL), was added [RhCl(cod)]2 (0.27 mg, 0.55 μmol), and 1,2-bis(diphenylphosphino)ethane (0.44 mg, 1.1 μmol) and was shaken until the solution was homogeneous. After addition of aniline (10 μL, 110 μmol), the resulting mixture was transferred to the micro-autoclave, which was pre-charged with [11C]CO. The autoclave (250 μL) was heated at 120° C. for 5 min under 35 MPa and the crude product was transferred to a reduced pressure vial. The radioactivity was measured before and after the vial was flushed with N2 (the [11C]CO-trapping efficiency of 82% was determined based on these values). A small amount of crude product was collected and analyzed by the reversed phase HPLC. Yield of product: 82%. The product was identified by HPLC with an added authentic reference compound.

Source