Reaction #486516

Reaction equation

2e

1,3-dichloro-3-fluoro-7-oxabicyclo[4.1.0]heptane

alcohol

1-methyl-2,2,6,6-tetrachlorocyclohexanol

sodium hydroxide

→

epoxide

Yield 95.5%

1,3,3-trichloro-2-methyl-7-oxabicyclo[4.1.0]heptane

Yield 95.5%

Solvents

water

Conditions

Workup

1. 1
   Otherreaction time
2. 2
   Extractionether extraction (5×40 cm3)

Procedure

The same procedure was employed as for the preparation of 2e in Example 17: it was performed with 3.97 g (15.75 mmol) of crude alcohol 1j, 20 cm3 of distilled water and 2.4 g (60 mmol) of sodium hydroxide; reaction time was 1 h 15 min; ether extraction (5×40 cm3); 3.29 g of epoxide 2h were obtained having a 95.5% yield based on the ketone (macrobore GC purity>99%)

Source