Reaction #48573

ord-0fffafacf1e4463483c5004df7b61637

Reaction equation

O=C(Nc1ccc(F)cc1)c1n[nH]cc1NC1CCCCC1
compound
O=C(Nc1ccc(F)cc1)c1n[nH]cc1NC1CCCCC1
4-Cyclohexylamino-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide
O=C1CCCCC1
cyclohexanone
C=O
formaldehyde
→
CN(c1c[nH]nc1C(=O)Nc1ccc(F)cc1)C1CCCCC1
4-(Cyclohexyl-methyl-amino)-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide

Reactants

O=C(Nc1ccc(F)cc1)c1n[nH]cc1NC1CCCCC1
compound
O=C(Nc1ccc(F)cc1)c1n[nH]cc1NC1CCCCC1
4-Cyclohexylamino-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide
O=C1CCCCC1
cyclohexanone
C=O
formaldehyde

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

This compound was prepared in a manner analogous to the compound of Example 19 by successive reductive alkylations using firstly cyclohexanone and then formaldehyde. (LC/MS: Rt 2.77 [MH]+ 316.71).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07745638B2uspto-grants-2010_06