Reaction #47736

Reaction equation

Glutaric anhydride

3-ethynylaniline

→

product

Yield 99.0%

4-(3-Ethynyl-phenylcarbamoyl)-butyric acid

Yield 99.0%

Solvents

dichloromethane

Conditions

Workup

1. 1
   Otherwas evaporated under reduced pressure

Procedure

Glutaric anhydride (215 mg, 1.9 mmol) was dissolved in anhydrous dichloromethane (7 ml) and followed by the addition of 3-ethynylaniline (200 mg, 1.7 mmol). The mixture was allowed to stir at room temperature for 6 hours before the solvent was evaporated under reduced pressure to provide the product as a white solid (363 mg, 99%);

Source