Reaction #47725

Reaction equation

N2,4-dip-tolylpyridine-2,3-diamine

2-(ethoxymethylene)malonnitrile

→

3,7-dip-tolyl-3H-imidazo[4,5-b]pyridine

Yield 84.0%

Solvents

isopropanol

Conditions

Workup

1. 1
   Temperaturerefluxed for 6 hours
2. 2
   OtherThe solution was removed
3. 3
   Otherwas purified
4. 4
   Otherto thereby produce a solid crystalline product at a yield of 84%

Procedure

0.70 mol of N2,4-dip-tolylpyridine-2,3-diamine and 2.56 mol of 2-(ethoxymethylene)malonnitrile were added in 10 ml of isopropanol, and refluxed for 6 hours. The solution was removed and was purified by using column chromatography to thereby produce a solid crystalline product at a yield of 84%.

Source