Reaction #476540

Reaction equation

gabapentin

tetrabutylammonium hydroxide

→

title compound ( 11 )

Tetrabutylammonium 1-Aminomethyl-1-Cyclohexane Acetate

Solvents

methanol

methanol

Conditions

Workup

1. 1
   OtherThe solvent was removed in vacuo
2. 2
   workup.ADDITIONtoluene (200 mL) was added
3. 3
   Otherevaporated under reduced pressure two times

Procedure

A solution containing gabapentin (34.4 g, 200 mmol), a 1 M solution of tetrabutylammonium hydroxide in methanol (200 mL, 200 mmol), and additional methanol (200 mL) was stirred at ambient temperature for 14 h. The solvent was removed in vacuo, then toluene (200 mL) was added and evaporated under reduced pressure two times. The title compound (11) was obtained as a thick syrup, and was further dried under high vacuum and used without further purification.

Source