Reaction #476407

Reaction equation

potassium chloride

potassium acetate

acetic acid

2-chloroacetophenone

→

2-acetoxyacetophenone

Yield 79.3%

Solvents

water

ethanol

Conditions

Workup

1. 1
   TemperatureAfter completion of heating
2. 2
   Filtrationwas filtered off
3. 3
   workup.DISTILLATIONthe ethanol was distilled off in vacuo
4. 4
   Otherto obtain a pale brown oily material
5. 5
   Filtrationa precipitated solid was collected by filtration
6. 6
   Otherrecrystallized from methanol

Procedure

78.5 g (0.80 mol) of potassium acetate, 5.0 g (0.08 mol) of acetic acid, and 123.7 g (0.80 mol) of 2-chloroacetophenone were heated under reflux in 500 mL of ethanol for 6 hours. After completion of heating, the reaction mixture was cooled to room temperature, deposited potassium chloride was filtered off, and the ethanol was distilled off in vacuo to obtain a pale brown oily material. This oily material was poured into one litter of water, and a precipitated solid was collected by filtration and recrystallized from methanol to obtain 113.1 g (yield: 79.3%) of 2-acetoxyacetophenone as a pale yellow solid.

Source