Reaction #4724

Reaction equation

Hydrogen peroxide

N-methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarbothioamide

→

N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

Solvents

ethanol

Conditions

Workup

1. 1
   Temperaturethe reaction mixture is briefly heated to boiling
2. 2
   FiltrationThe sulphur which separates is filtered off hot with the aid of active charcoal
3. 3
   Concentrationthe filtrate is concentrated by evaporation
4. 4
   Otherpurified by preparative layer chromatography

Procedure

2 ml of 30% Hydrogen peroxide are added to 1.58 g (4 mmol) of N-methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarbothioamide in 30 ml of ethanol and the reaction mixture is briefly heated to boiling. The sulphur which separates is filtered off hot with the aid of active charcoal and the filtrate is concentrated by evaporation and purified by preparative layer chromatography.

Source