Reaction #4712

Reaction equation

methylisothiocyanate

N-[3-[3-(1-piperidinylmethyl) phenoxy]propyl]-hydrazine carboxamide

→

2-(Methylaminothioxomethyl)-N-[3-[3-(1-piperidinylmethyl)phenoxy]-propyl]-hydrazine carboxamide

Solvents

THF

Conditions

Workup

1. 1
   OtherThe precipitate obtained
2. 2
   Filtrationis filtered off
3. 3
   Otherrecrystallised from ethanol

Procedure

0.5 g (6.6 mmol) of methylisothiocyanate are added to 1.0 g (3.3 mmol) of N-[3-[3-(1-piperidinylmethyl) phenoxy]propyl]-hydrazine carboxamide in 20 ml of THF and the mixture is stirred at room temperature for 12 hours. The precipitate obtained is filtered off and recrystallised from ethanol. The analytical values are summarized in Table I.

Source