Reaction #4705

Reaction equation

N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide

methylisocyanate

Ether

→

N-Methyl-2-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]aminothioxomethyl]-hydrazine carboxamide

Solvents

THF

Conditions

Workup

1. 1
   workup.WAITthe reaction mixture is left
2. 2
   Otherthe precipitation
3. 3
   Filtrationfiltered
4. 4
   Washwashed with ether
5. 5
   Otherrecrystallised from ethanol

Procedure

1.62 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide are dissolved in 30 ml of THF, 0.40 g (6 mmol) of methylisocyanate are added and the reaction mixture is left to stand overnight at room temperature. Ether is added to complete the precipitation, and the precipitate is suction filtered, washed with ether and recrystallised from ethanol. The analytical values are summarized in Table I.

Source