Reaction #470420

Reaction equation

4′,7-Dihydroxyisoflav-3-ene

p-toluidine

ethanol

Formaldehyde

→

title compound

Yield 22.0%

4-(3-p-Tolyl-2,3,4,8-tetrahydrochromeno[6,7-e][1,3]oxazin-7-yl)phenol

Yield 22.0%

Conditions

Workup

1. 1
   OtherThe resulting precipitate was collected

Procedure

4′,7-Dihydroxyisoflav-3-ene (499 mg, 2.08 mmol) and p-toluidine (290 mg, 2.71 mmol) were dissolved in ethanol (8 ml). Formaldehyde solution (2 ml, 0.03 mol, 37% wt) was added and the reaction stirred at room temperature for 2 days. The resulting precipitate was collected to afford the title compound (167 mg, 22%).

Source