Reaction #470391

Reaction equation

2-phenyl-1H-benzo[d]imidazole

ethanol

→

desired product

1-(2-isopropylphenyl)-2-phenyl-1H-benzo[d]imidazole

Conditions

Workup

1. 1
   TemperatureThe mixture was heated up
2. 2
   Temperatureto reflux for 24 hours
3. 3
   Filtrationthe precipitate was collected by filtration
4. 4
   OtherThe product was purified by column chromatography

Procedure

Intermediate 1 (1.5 g, 2.1 mmol) and 142-isopropylphenyl)-2-phenyl-1H-benzo[d]imidazole (2 g, 6.4 mmol) were mixed with 30 ml of ethanol in a three-neck flask under nitrogen. The mixture was heated up to reflux for 24 hours. After cooled to room temperature, the precipitate was collected by filtration. The product was purified by column chromatography using 1:2 dichloromethane and hexanes as eluent. 0.7 g of desired product was obtained after purification.

Source