Reaction #470368

Reaction equation

sodium acetate

N-methoxymethyl-N-methylpyrrolidinium chloride

N-Methyl-N-Methoxymethylpyrrolidinium Chloride

→

desired product

N-Methoxymethyl-N-Methylpyrrolidinium Acetate

Solvents

methanol

Conditions

Workup

1. 1
   OtherThe mixture was reacted at room temperature for 1.5 hours
2. 2
   Otherwhereby the reaction was terminated
3. 3
   FiltrationThe reaction mixture was filtered
4. 4
   Concentrationthe filtrate was concentrated
5. 5
   Otherdried in a vacuum
6. 6
   workup.ADDITIONTo the residue was added 100 ml of dichloromethane
7. 7
   Filtrationfollowed by filtration with a membrane
8. 8
   Filtrationfilter
9. 9
   Concentrationconcentration in a vacuum
10. 10
    Otherdrying

Procedure

A 9.46 g quantity of sodium acetate (product of Wako Pure Chemical Ind. Ltd.) was dissolved in 95 g of methanol, and 19.10 g of N-methoxymethyl-N-methylpyrrolidinium chloride was added to the solution. The mixture was reacted at room temperature for 1.5 hours, whereby the reaction was terminated. The reaction mixture was filtered, and the filtrate was concentrated and dried in a vacuum. To the residue was added 100 ml of dichloromethane, followed by filtration with a membrane filter, concentration in a vacuum and drying, affording 20.38 g of the desired product.

Source