Reaction #4701

Reaction equation

N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide

methyl isothiocyanate

Ether

→

N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,2-hydrazine dicarbothioamide

Solvents

THF

Conditions

Workup

1. 1
   workup.WAITthe reaction mixture is left
2. 2
   Otherthe precipitate formed
3. 3
   Filtrationfiltered
4. 4
   Washwashed with ether
5. 5
   Otherrecrystallised from ethanol

Procedure

1.62 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide are dissolved in 30 ml of THF, 0.44 g (6 mmol) of methyl isothiocyanate are added, and the reaction mixture is left to stand overnight at room temperature. Ether is added to complete precipitation and the precipitate formed is suction filtered, washed with ether and recrystallised from ethanol. The analytical values are summarized in Table I.

Source