Reaction #465975

Reaction equation

methyl-4-amino-6-bromo-5-chloro-3-methoxypyridine-2-carboxylate

NaOH

→

white fluffy solid

Yield 80.1%

4-Amino-6-bromo-5-chloro-3-methoxypyridine-2-carboxylic Acid

Yield 80.1%

Solvents

methanol

Conditions

Workup

1. 1
   Concentrationwas then concentrated to dryness in vacuo
2. 2
   FiltrationThe white solid was collected by filtration
3. 3
   Washwas rinsed with H2O
4. 4
   OtherThe solid was dried at 50° C. under vacuum

Procedure

To methyl-4-amino-6-bromo-5-chloro-3-methoxypyridine-2-carboxylate (0.300 g, 1.02 mmol) in 10 mL of methanol was added 1 N NaOH (1.10 mL, 1.10 mmol). The reaction mixture was stirred at room temperature for 4 hr and was then concentrated to dryness in vacuo. The resulting aqueous layer was acidified with concentrated HCl. The white solid was collected by filtration and was rinsed with H2O. The solid was dried at 50° C. under vacuum to give 0.230 g of a white fluffy solid; mp 154-156° C.

Source