Reaction #465964

Reaction equation

methyl 3-chloro-5-methoxy-4-nitro-pyridine-2-carboxylate

PCl3

→

white solid

Methyl 3,6-Dichloro-5-methoxy-4-nitropyridine-2-carboxylate

Solvents

chloroform

Conditions

Workup

1. 1
   TemperatureThe reaction mixture was heated
2. 2
   Temperatureto reflux for 8 hr
3. 3
   Concentrationconcentrated to dryness in vacuo

Procedure

To methyl 3-chloro-5-methoxy-4-nitro-pyridine-2-carboxylate, N-oxide (0.300 g, 1.12 mmol) in 5 mL of chloroform was added PCl3 (0.664 mL, 7.62 mmol). The reaction mixture was heated to reflux for 8 hr and then concentrated to dryness in vacuo to give 300 mg of a white solid.

Source