Reaction #46348

Reaction equation

2-(Chloropyrid-5-yl)-(4-chlorophenyl)bromo-methane

4-chlorophenylmagnesium bromide

2-chloropyridine-5-carboxaldehyde

→

2-(chloropyrid-5-yl)-(4-chlorophenyl)methanol

Solvents

tetrahydrofuran

tetrahydrofuran

Conditions

Procedure

2-(Chloropyrid-5-yl)-(4-chlorophenyl)bromo-methane may be prepared by carrying out the procedure in a manner similar to Example 84, starting with 22.5 cm3 of 4-chlorophenylmagnesium bromide (1 M solution in ethyl ether) in 30 cm3 of tetrahydrofuran, under an inert argon atmosphere, and 2.9 g of 2-chloropyridine-5-carboxaldehyde in 30 cm3 of tetrahydrofuran. 3.42 g of 2-(chloropyrid-5-yl)-(4-chlorophenyl)methanol are thus obtained in the form of a pale green powder.

Source