Reaction #46328

Reaction equation

Dihexylamine

3,4-diethyloxy-1,1-dioxo-1,2,5-thiadiazole

→

title intermediate

Yield 72.4%

4-(N,N-Di-n-hexylamino)-3-ethoxy-1,1-dioxo-1,2,5-thiadiazole

Yield 72.4%

Solvents

ethanol

Conditions

Workup

1. 1
   OtherThe solvent was removed under reduced pressure
2. 2
   Otherthe residue absorbed onto silica gel
3. 3
   Otherand purified by flash column chromatography (silica, hexane:EtOAc 3:1)

Procedure

Dihexylamine (90 mg, 0.48 mmol) was added to a solution of 3,4-diethyloxy-1,1-dioxo-1,2,5-thiadiazole (100 mg, 0.48 mmol) in ethanol (5 mL) and the reaction stirred overnight at room temperature. The solvent was removed under reduced pressure and the residue absorbed onto silica gel; and purified by flash column chromatography (silica, hexane:EtOAc 3:1) to yield the title intermediate (120 mg, 72%).

Source