Reaction #463207

Reaction equation

tetrafluorophthalic anhydride

lithium hydroxide hydrate

trifluoroethanol

tetrafluorophthalic anhydride

→

3-trifluoroethoxy-2,4,5-trifluorobenzoic acid

Yield 51.0%

Solvents

water

Conditions

Workup

1. 1
   workup.ADDITIONAn initial charge

Procedure

An initial charge comprising a mixture of 7.6 g of water, 2.1 g of lithium hydroxide hydrate, 10 g of trifluoroethanol and 2.2 g (10 mmol) of tetrafluorophthalic anhydride is heated at 70° C. for 96 hours, after which the content of tetrafluorophthalic anhydride has fallen to below 1% (GC). The procedure described in Example 3 is then followed to give 1.4 g (5.1 mmol, corresponding to 51%) of 3-trifluoroethoxy-2,4,5-trifluorobenzoic acid.

Source