Reaction #46123

Reaction equation

7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxide

potassium carbonate

cyclopropylmethyl bromide

→

7-chloro-4-cyclopropylmethyl-4H-1,2,4-benzothiadiazine 1,1-dioxide

Solvents

acetonitrile

Conditions

Workup

1. 1
   Temperaturethe mixture is heated
2. 2
   Temperatureat reflux for 24 hours
3. 3
   OtherThe reaction mixture is evaporated under reduced pressure
4. 4
   FiltrationThe insoluble material is collected by filtration
5. 5
   Washwashed with water
6. 6
   Otherdried
7. 7
   Otheris recrystallised from methanol

Procedure

To a solution of 7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxide (1 g) in acetonitrile (40 mL) there is added potassium carbonate (2.5 g) and cyclopropylmethyl bromide (0.7 mL) and the mixture is heated at reflux for 24 hours. The reaction mixture is evaporated under reduced pressure and the residue is taken up in water (40 mL). The insoluble material is collected by filtration, washed with water and dried and is recrystallised from methanol.

Source