Reaction #46023

Reaction equation

product

2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-1-(4-pyridin-4-yl-piperazin-1-yl)-ethanone

BH3-THF

→

1-[2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethyl]-4-pyridin-4-yl-piperazine

Solvents

THF

Conditions

Workup

1. 1
   Temperaturethe reaction was heated
2. 2
   Temperatureto reflux until the reaction
3. 3
   OtherThe crude product was purified by silica gel chromatography
4. 4
   Otherto afford Example 527

Procedure

The product of Example 522 was taken in 4 ml of THF to which was added 5 eq. of BH3-THF solution and the reaction was heated to reflux until the reaction was complete. The crude product was purified by silica gel chromatography to afford Example 527.

Source