Reaction #45913

Reaction equation

Benzyl (3S)-3-[(tert-butoxycarbonyl)(methyl)amino]-3-methylpyrrolidine-1-carboxylate

→

crude product

tert-Butyl methyl[(3S)-3-methylpyrrolidin-3-yl]carbamate

Solvents

1,4-dioxane

Conditions

Workup

1. 1
   OtherThe reaction liquid
2. 2
   Filtrationwas filtered
3. 3
   Concentrationthe filtrate was concentrated under reduced pressure

Procedure

Benzyl (3S)-3-[(tert-butoxycarbonyl)(methyl)amino]-3-methylpyrrolidine-1-carboxylate (I-347) (367 mg, 1.05 mmol) was dissolved in 1,4-dioxane (10 ml), then palladium hydroxide catalyst (37 mg) was added, followed by stirring under hydrogen atmosphere at room temperature for 5 hours. The reaction liquid was filtered, and the filtrate was concentrated under reduced pressure to obtain a crude product of the entitled compound. This was used in the next reaction as such.

Source