Reaction #458906

Reaction equation

ethanol

1-aminomethyl-1-cyclohexane-acetic acid

hydrogen chloride

→

Ethyl 1-aminomethyl-1-cyclohexane-acetate

hydrochloride

Conditions

Workup

1. 1
   workup.DISSOLUTIONare dissolved in 50 ml
2. 2
   Othersaturated at 0° C.
3. 3
   workup.WAITThe reaction mixture is left
4. 4
   Otherevaporated in a vacuum
5. 5
   Otherthe residue recrystallised from ethanol/ether

Procedure

10 g. of the 1-aminomethyl-1-cyclohexane-acetic acid, prepared according to Example 1, are dissolved in 50 ml. anhydrous ethanol and saturated at 0° C. with gaseous hydrogen chloride. The reaction mixture is left to stand overnight at ambient temperature, then evaporated in a vacuum and the residue recrystallised from ethanol/ether. Ethyl 1-aminomethyl-1-cyclohexane-acetate is obtained in the form of its hydrochloride; m.p. 161° - 163° C.

Source