Reaction #453280

Reaction equation

4-hydroxy-2-fluorobenzoic acid

acetic acid

→

4-acetoxy-2-fluorobenzoic acid

Solvents

water

Conditions

Workup

1. 1
   workup.ADDITIONmixed
2. 2
   TemperatureAfter heat generation
3. 3
   Otherterminated
4. 4
   Filtrationa precipitated crystal was recovered by filtration

Procedure

4.3 Grams of 4-hydroxy-2-fluorobenzoic acid and 8.4 g of anhydrous acetic acid were placed in a two-necked flask and mixed, and five drops of sulfuric acid was added with cooling with water. After heat generation terminated, the mixture was heated at 80° C. for 30 minutes. Then, the reaction mixture was discharged into cold water, and a precipitated crystal was recovered by filtration.

Source