Reaction #452559

Reaction equation

Benzyl chloroformate

cyclopentylmethylamine

DIEA

→

N-Cbz-cyclopentylmethylamine

Yield 121.7%

Solvents

CH2Cl2

Conditions

Workup

1. 1
   ConcentrationThe mixture was concentrated in vacuo
2. 2
   Washwashed with water, sat. aq. NaHCO3, brine
3. 3
   Dryingdried over MgSO4
4. 4
   Concentrationconcentrated

Procedure

Benzyl chloroformate (0.919 g, 5.38 mmol) was added to a solution of cyclopentylmethylamine (0.445 g, 4.49 mmol) and DIEA (1.74 g, 13.5 mmol) in 50 mL of CH2Cl2 and the mixture was strried overnight at R.T. The mixture was concentrated in vacuo and the residue was taken up in EtOAc, washed with water, sat. aq. NaHCO3, brine, dried over MgSO4 and concentrated to give the crude N-Cbz-cyclopentylmethylamine (1.275 g) which was used without further purification. 1H NMR consistent with structure.

Source