Reaction #452487

Reaction equation

1-(2-Quinolylcarbonyl)piperazine hydrochloride

sodium hydroxide

→

title compound

Yield 79.1%

1-(2-quinolylcarbonyl)piperazine

Yield 79.1%

Solvents

water

Conditions

Workup

1. 1
   ExtractionThe resulting mixture was extracted with chloroform
2. 2
   Washthe extract was washed with an aqueous solution of sodium chloride
3. 3
   Dryingdried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONThe solvent was distilled off

Procedure

1-(2-Quinolylcarbonyl)piperazine hydrochloride (6.18 g, 22.2 mmol) was dissolved in water. The thus-obtained solution was rendered basic with a concentrated aqueous solution of sodium hydroxide. The resulting mixture was extracted with chloroform, and the extract was washed with an aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was distilled off, whereby 4.236 g of the title compound were obtained as a colorless oil (yield: 79.1%).

Source