Reaction #452478

Reaction equation

product

3-[4-(2-Methoxyphenyl)piperazin-1-yl]propionitrile

→

product

Yield 86.9%

4-(2-Methoxyphenyl)-1-(3-aminopropyl)piperazine

Yield 86.9%

Solvents

ammonia

Conditions

Procedure

A solution of the product of Example 26 (4.4 g, 18 mmol) in concentrated ethanolic ammonia solution (150 ml) was hydrogenated over 5% rhodium on alumina powder (0.6 g) at 50 p.s.i. (about 3.4×105Pa) for 50 h to give the product (3.9 g) as a brown oil.

Source