Reaction #452424

Reaction equation

N-(4-fluorobenzoyl)-4-nitroaniline

→

N-(4-fluoro-benzoyl)-4-aminoaniline

Yield 79.0%

Solvents

tetrahydrofuran

Conditions

Workup

1. 1
   FiltrationThe reaction mixture was then filtered
2. 2
   Concentrationthe filtrate concentrated under reduced pressure

Procedure

A mixture of 32.25 gm (124 mMol) N-(4-fluorobenzoyl)-4-nitroaniline and 3.2 gm platinum on carbon in 500 mL tetrahydrofuran was hydrogenated at room temperature for 18 hours with an initial pressure of 60 p.s.i. The reaction mixture was then filtered and the filtrate concentrated under reduced pressure to give 22.45 gm (79%) of N-(4-fluoro-benzoyl)-4-aminoaniline.

Source