Reaction #452414

Reaction equation

n-butyl bromide

NaHCO3

m-aminophenol

→

3-(n-butylamino)phenol

Yield 57.0%

Solvents

methanol

Conditions

Workup

1. 1
   Temperaturethe mixture is refluxed for 5 h
2. 2
   TemperatureAfter cooling
3. 3
   Filtrationit is filtered
4. 4
   Otherthe solvent is removed in vacuo

Procedure

0.11 mol of n-butyl bromide and 0.1 mol NaHCO3 are added to 0.1 mol of m-aminophenol in 150 ml of methanol, and the mixture is refluxed for 5 h. After cooling, it is filtered and the solvent is removed in vacuo. The oil which remains is fractionated in vacuo, to give 3-(n-butylamino)phenol.

Source