Reaction #44885

ord-0fb8e1043ae94a52b72a56411923d592

Reaction equation

CC(C)n1c(=O)[nH]c2ccccc21
1-isopropyl-1,3-dihydro-2H-benzimidazol-2-one
CCC(CC)(CN1CCC(CNC(=O)OC(C)(C)C)CC1)C(=O)OC
Methyl 2-[(4-{[(tert-butoxycarbonyl)amino]methyl}piperidin-1-yl)methyl]-2-ethylbutanoate
CCC(CC)(CN1CCC(CNC(=O)OC(C)(C)C)CC1)C(=O)OC
Methyl 2-[(4{[(tert-butoxycarbonyl)amino]methyl}piperidin-1-yl)methyl]-2-ethylbutanoate
→
CCC(CC)(CN1CCC(CNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1)C(=O)OC
title compound
CCC(CC)(CN1CCC(CNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1)C(=O)OC
Methyl 2-ethyl-2-{[4-({[(3-isopropyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)carbonyl]amino}methyl)piperidin-1-yl]methyl}butanoate

Reactants

CC(C)n1c(=O)[nH]c2ccccc21
1-isopropyl-1,3-dihydro-2H-benzimidazol-2-one
CCC(CC)(CN1CCC(CNC(=O)OC(C)(C)C)CC1)C(=O)OC
Methyl 2-[(4-{[(tert-butoxycarbonyl)amino]methyl}piperidin-1-yl)methyl]-2-ethylbutanoate
CCC(CC)(CN1CCC(CNC(=O)OC(C)(C)C)CC1)C(=O)OC
Methyl 2-[(4{[(tert-butoxycarbonyl)amino]methyl}piperidin-1-yl)methyl]-2-ethylbutanoate

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound was prepared according to the procedure described in Step 2 of Example 8 from 1-isopropyl-1,3-dihydro-2H-benzimidazol-2-one and Methyl 2-[(4-{[(tert-butoxycarbonyl)amino]methyl}piperidin-1-yl)methyl]-2-ethylbutanoate (step 1 of Example 13).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07737163B2uspto-grants-2010_06