Reaction #44484

ord-272aeb37cfe24c39bb51f81365c79ccf

Reaction equation

CC(C)(C)[SiH2]OC(C)(C)C1CN(C2CCCCCC2)C(=O)C1(C)C
solution
CC(C)(C)[SiH2]OC(C)(C)C1CN(C2CCCCCC2)C(=O)C1(C)C
4-(tert-Butyl-dimethyl-silanyloxymethyl)-1-cycloheptyl-3,3-dimethyl-pyrrolidin-2-one
→
CC1(C)C(=O)N(C2CCCCCC2)CC1CO
title compound
CC1(C)C(=O)N(C2CCCCCC2)CC1CO
1-Cycloheptyl-4-hydroxymethyl-3,3-dimethyl-pyrrolidin-2-one

Reactants

CC(C)(C)[SiH2]OC(C)(C)C1CN(C2CCCCCC2)C(=O)C1(C)C
solution
CC(C)(C)[SiH2]OC(C)(C)C1CN(C2CCCCCC2)C(=O)C1(C)C
4-(tert-Butyl-dimethyl-silanyloxymethyl)-1-cycloheptyl-3,3-dimethyl-pyrrolidin-2-one

Reagents

Cl
HCl

Solvents

CO
methanol

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThe solvent was evaporated in vacuo

Procedure

Two drops of 12M HCl was added to a solution of Example 1D (75 mg, 0.21 mmoles) in methanol (1.25 mL) and stirred for one hour at room temperature. The solvent was evaporated in vacuo to provide the title compound as a colorless oil.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07737137B2uspto-grants-2010_06