Reaction #44459

Reaction equation

trans-N-(12-bromo-7-chloro-2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido-[1,2-d][1,4]oxazepin-1-yl)-2,2,2-trifluoroacetamide

Methylzinc chloride

NH4Cl

→

title compound

trans-N-(7-Chloro-2,3,4,14b-tetrahydro12-methyl-1H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepin-1-yl)-2,2,2-trifluoroacetamide

Solvents

THF

Conditions

Workup

1. 1
   workup.STIRRINGstirred overnight at 60° C
2. 2
   workup.ADDITIONThe mixture was poured
3. 3
   Extractionextracted with ethyl acetate (3×)
4. 4
   WashThe combined organic layers were washed with brine
5. 5
   Dryingdried (Na2SO4)
6. 6
   Otherevaporated
7. 7
   OtherAfter purification on silica

Procedure

To a solution of trans-N-(12-bromo-7-chloro-2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido-[1,2-d][1,4]oxazepin-1-yl)-2,2,2-trifluoroacetamide (80 mg, 0.17 mmol) in THF (2 mL) was added ferrocene PdCl2 (5 mg, 7 μmol), and the reaction mixture was stirred for 5 min. Methylzinc chloride was added dropwise whereafter the reaction mixture was heated to 60° C. and stirred overnight at 60° C. The mixture was poured into sat (aq) NH4Cl and extracted with ethyl acetate (3×). The combined organic layers were washed with brine, dried (Na2SO4) and evaporated. After purification on silica and with HPLC the title compound was obtained (13.2 mg, 19%). Data: 1H-NMR (400 MHz, DMSO) 1.60-1.85 (m, 3H), 2.0 (m, 1H), 2.23 (s, 3H), 3.11 (td, J=2.8, 13.2, 1H), 3.85 (d, J=14, 1H), 4.10 (d, J=10, 1H), 4.40 (m, 1H), 6.69-7.10 (6 ArH), 9.16 (d, J=10, 1H).

Source