Reaction #443973

Reaction equation

tyrosine

tetramethylene sulfone

glutamic acid

phenylalanine

aspartic acid

→

Glu Asp Tyr Phe

Solvents

water

Conditions

Workup

1. 1
   Temperaturethe mixture was heated for one-half hour
2. 2
   Temperaturethe mixture heated at 190° C. for 3 hours
3. 3
   Temperaturethe mixture heated at 190° C. for 1.5 hours
4. 4
   workup.STIRRINGAfter stirring for about 1 hour
5. 5
   Filtrationthe mixture was filtered
6. 6
   Filtrationfiltered
7. 7
   OtherThe pH of the slurry (at 25° C.)
8. 8
   FiltrationThe mixture was filtered
9. 9
   Washthe cake washed with a small amount of water
10. 10
    Otherevaporated to dryness in vacuo

Procedure

750 ml of tetramethylene sulfone was heated to 190° C. in an inert nitrogen atmosphere in a 4 liter flask with stirring. 294 g of glutamic acid was added and the mixture was heated for one-half hour. 266 g of aspartic acid was added and the mixture heated as rapidly as possible to 190° C. and held there for 15 minutes. 362 g of tyrosine was added and the mixture heated at 190° C. for 3 hours. 330 g of phenylalanine was added and the mixture heated at 190° C. for 1.5 hours. The hot melt was then poured into 5 liters of water with vigorous stirring. After stirring for about 1 hour, the mixture was filtered and the filtrate discarded. The cake was reslurried in 5 liters of water, filtered and the cake was again reslurried in 5 liters of water. The pH of the slurry (at 25° C.) was adjusted to 8 using 40% sodium hydroxide solution. The mixture was filtered and the cake washed with a small amount of water. The washes and filtrate are combined and evaporated to dryness in vacuo to give Glu/Asp/Tyr/Phe proteinoid.

Source