Reaction #4433

Reaction equation

2-chloro-3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-4-(2,4,6-trimethylphenylimino)pyrimidine

1,2,3,6-tetrahydropyridine

→

3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-2-(1,2,3,6-tetrahydropyridin-1-yl)-4-(2,4,6-trimethylphenylimino)pyrimidine

Solvents

ethanol

Conditions

Workup

1. 1
   Temperaturerefluxed for 1.5 hours
2. 2
   OtherThe resulting precipitates
3. 3
   Otherwere collected
4. 4
   workup.DISSOLUTIONdissolved in chloroform
5. 5
   Washwashed with aqueous sodium bicarbonate solution
6. 6
   Dryingdried over magnesium sulfate
7. 7
   OtherAfter evaporated
8. 8
   Otherthe residue was triturated with diisopropyl ether

Procedure

To a suspension of 2-chloro-3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-4-(2,4,6-trimethylphenylimino)pyrimidine (2.08 g) in ethanol (20 ml) was added 1,2,3,6-tetrahydropyridine (1.38 ml), and refluxed for 1.5 hours. The resulting precipitates were collected, dissolved in chloroform, washed with aqueous sodium bicarbonate solution, and dried over magnesium sulfate. After evaporated, the residue was triturated with diisopropyl ether to give 3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-2-(1,2,3,6-tetrahydropyridin-1-yl)-4-(2,4,6-trimethylphenylimino)pyrimidine (1.95 g).

Source