Reaction #44148

ord-05d45e2a3c694c1eb21132310d12dc60

Reaction equation

Cc1ccc2c(N3CCN(CCc4cc(Br)ccc4F)CC3)cccc2n1
5-{4-[2-(5-bromo-2-fluorophenyl)ethyl]-1-piperazinyl}-2-methylquinoline
CS(N)(=O)=O
methanesulfonamide
→
Cc1ccc2c(N3CCN(CCc4cc(NS(C)(=O)=O)ccc4F)CC3)cccc2n1
title compound
Yield 69.0%
Cc1ccc2c(N3CCN(CCc4cc(NS(C)(=O)=O)ccc4F)CC3)cccc2n1
N-(4-Fluoro-3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)methanesulfonamide
Yield 69.0%

Reactants

Cc1ccc2c(N3CCN(CCc4cc(Br)ccc4F)CC3)cccc2n1
5-{4-[2-(5-bromo-2-fluorophenyl)ethyl]-1-piperazinyl}-2-methylquinoline
—
amides
—
ureas
—
carbamates
CS(N)(=O)=O
methanesulfonamide

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound was prepared in 69% yield according to the general procedure for the preparation of amides, ureas and carbamates (Method A) starting from 5-{4-[2-(5-bromo-2-fluorophenyl)ethyl]-1-piperazinyl}-2-methylquinoline and methanesulfonamide.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732600B2uspto-grants-2010_06