Reaction #44145

ord-800a26bd045545dd92f90a7e97ea1aed

Reaction equation

Cc1ccc2c(N3CCN(CCc4cc(Br)ccc4F)CC3)cccc2n1
5-{4-[2-(5-bromo-2-fluorophenyl)ethyl]-1-piperazinyl}-2-methylquinoline
CC(N)=O
acetamide
→
CC(=O)Nc1ccc(F)c(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
title compound
Yield 66.0%
CC(=O)Nc1ccc(F)c(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
N-(4-Fluoro-3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)acetamide
Yield 66.0%

Reactants

Cc1ccc2c(N3CCN(CCc4cc(Br)ccc4F)CC3)cccc2n1
5-{4-[2-(5-bromo-2-fluorophenyl)ethyl]-1-piperazinyl}-2-methylquinoline
—
amides
—
ureas
—
carbamates
CC(N)=O
acetamide

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound was prepared in 66% yield according to the general procedure for the preparation of the amides, ureas and carbamates (Method A) starting from 5-{4-[2-(5-bromo-2-fluorophenyl)ethyl]-1-piperazinyl}-2-methylquinoline and acetamide.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732600B2uspto-grants-2010_06