Reaction #44076

ord-689dc4193431451b8b481e2ca2d80810

Reaction equation

Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cccc2n1
3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline
Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cccc2n1
3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline
O=C(Cl)C1CC1
cyclopropanecarbonyl chloride
→
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C5CC5)c4)CC3)cccc2n1
title compound
Yield 70.0%
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C5CC5)c4)CC3)cccc2n1
N-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)cyclopropane carboxamide
Yield 70.0%

Reactants

—
amides
Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cccc2n1
3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline
Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cccc2n1
3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline
O=C(Cl)C1CC1
cyclopropanecarbonyl chloride

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound was prepared in 70% yield according to the general procedure for the preparation of the amides (Method B) starting from 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (D6) and cyclopropanecarbonyl chloride.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732600B2uspto-grants-2010_06