Reaction #44072

Reaction equation

3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

5-methyl-3-isoxazolecarbonyl chloride

→

title compound

Yield 40.0%

5-Methyl-N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-3-isoxazolecarboxamide

Yield 40.0%

Conditions

Procedure

The title compound was prepared in 40% yield according to the general procedure for the preparation of the amides (Method B) starting from 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (D6) and 5-methyl-3-isoxazolecarbonyl chloride.

Source