Reaction #43708

Reaction equation

2,6-dinitrobenzaldehyde

methyl mercaptoacetate

triethylamine

→

Methyl4-nitro-1-benzothiophene-2-carboxylate

Solvents

DMSO

Conditions

Workup

1. 1
   FiltrationThe resulting precipitate is filtered off with suction
2. 2
   Washwashed with water
3. 3
   Otherdried at 50° C. under reduced pressure overnight

Procedure

1.0 g (5.10 mmol) of 2,6-dinitrobenzaldehyde, 0.54 g (5.10 mmol) of methyl mercaptoacetate and 1.42 ml (10.20 mmol) of triethylamine in 3 ml of DMSO are heated at 80° C. for 3.5 h. The reaction solution is poured into 100 ml of ice-water. The resulting precipitate is filtered off with suction, washed with water and dried at 50° C. under reduced pressure overnight. This gives 1.10 g (88.7% of theory) of the title compound.

Source