Reaction #43700

Reaction equation

2,4-difluorobenzaldehyde

sodium hydride

methyl mercaptoacetate

→

desired product

Yield 67.3%

Methyl6-fluoro-1-benzothiophene-2-carboxylate

Yield 67.3%

Conditions

Procedure

Using 2.00 g (14.07 mmol) of 2,4-difluorobenzaldehyde, 0.84 g (21.11 mmol) of sodium hydride (60% pure) and 1.64 g (15.48 mmol) of methyl mercaptoacetate, 1.99 g of the desired product are obtained. The product is obtained in a purity which permits further reaction and is reacted without further purification.

Source