Reaction #43511

Reaction equation

4-hydroxy-4-(2-mercapto-5-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

1-iodo-4-methoxy-2-methyl-benzene

4-methoxy-2-methyl-phenylamine

→

1-tert-Butoxycarbonyl-4-[2-(4-methoxy-2-methyl-phenylsulfanyl)-5-fluoro-phenyl]-piperidine-4-ol

Conditions

Procedure

Prepared from 4-hydroxy-4-(2-mercapto-5-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester and 1-iodo-4-methoxy-2-methyl-benzene (prepared from 4-methoxy-2-methyl-phenylamine by diazotization according to the general procedure by Tunney and Stille J. Org. Chem. 1987, 52, 748-753).

Source