Reaction #4338

Reaction equation

( a )

2-(2-methylthioethoxy)-nitrobenzene

hydrogen

→

2-(2-methylthioethoxy)-aniline

Solvents

tetrahydrofuran

Conditions

Workup

1. 1
   FiltrationAfter the catalyst has been filtered off
2. 2
   Concentrationthe filtrate is concentrated by evaporation
3. 3
   Otherpurified by means of chromatography (silica gel; hexane/ethyl acetate as eluant)

Procedure

33.9 g of he oil obtained under (a) are hydrogenated in 100 ml of absolute tetrahydrofuran, with the addition of 13.6 g of Raney nickel, under normal pressure (hydrogen absorption=10.6 liters). After the catalyst has been filtered off, the filtrate is concentrated by evaporation, and then purified by means of chromatography (silica gel; hexane/ethyl acetate as eluant).

Source