Reaction #43377

ord-dcdbdac0a56e40299e8b1ada792d2b70

Reaction equation

CC(NC(=O)c1ccc(Cl)s1)C(=O)O
2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid
Nc1ccc(C(=O)N2CCCC2)c(Cl)c1
3-chloro-4-(pyrrolidin-1-yl-carbonyl)-aniline
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
CN1CCOCC1
NMM
→
CC(NC(=O)c1ccc(Cl)s1)C(=O)Nc1ccc(C(=O)N2CCCC2)c(Cl)c1
5-chloro-thiophene-2-carboxylic acid-N-{1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

Reactants

CC(NC(=O)c1ccc(Cl)s1)C(=O)O
2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid
Nc1ccc(C(=O)N2CCCC2)c(Cl)c1
3-chloro-4-(pyrrolidin-1-yl-carbonyl)-aniline
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
CN1CCOCC1
NMM

Reagents

None

Solvents

CN(C)C=O
DMF

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Prepared analogously to Example 1a from 2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid and 3-chloro-4-(pyrrolidin-1-yl-carbonyl)-aniline with TBTU and NMM in DMF.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732466B2uspto-grants-2010_06