Reaction #43375

ord-bb1475882c98444395d60f139ca030c2

Reaction equation

Cc1cc(Cl)sc1C(=O)O
methyl 5-chloro-thiophene-2-carboxylic acid
CC(N)C(=O)[O-]
2-aminopropionate
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
CN1CCOCC1
NMM
→
COC(=O)C(C)NC(=O)c1ccc(Cl)s1
methyl 2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionate

Reactants

Cc1cc(Cl)sc1C(=O)O
methyl 5-chloro-thiophene-2-carboxylic acid
CC(N)C(=O)[O-]
2-aminopropionate
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
CN1CCOCC1
NMM

Reagents

None

Solvents

C1CCOC1
THF

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Prepared analogously to Example 1a from methyl 5-chloro-thiophene-2-carboxylic acid and 2-aminopropionate with TBTU and NMM in THF.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07732466B2uspto-grants-2010_06