Reaction #433640

Reaction equation

7-hydroxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one

3-chlorobenzylbromide

potassium carbonate

→

7-(3-chloro-benzyloxy)-1,3,4,5-tetrahydro-benzo[d]azepin-2-one

Solvents

2-butanone

Conditions

Procedure

In an analogous manner to that described in Example 17 c), the alkylation of 7-hydroxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one [Example 19 b)] by 3-chlorobenzylbromide in the presence of potassium carbonate in 2-butanone yielded the 7-(3-chloro-benzyloxy)-1,3,4,5-tetrahydro-benzo[d]azepin-2-one as a white solid; MS: m/e=302 (M+H)+.

Source