Reaction #433630

Reaction equation

7-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride

methoxy-acetic acid chloride

N-ethyl-diisopropylamine

→

title compound

Yield 98.0%

1-[7-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl]-2-methoxy-ethanone

Yield 98.0%

Conditions

Workup

1. 1
   Otherwas prepared in analogy to Example 1 d

Procedure

The title compound was prepared in analogy to Example 1 d) from 7-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride [Example 1c)] and methoxy-acetic acid chloride with N-ethyl-diisopropylamine as the base. Yield: 98% of theory as a colourless oil; MS: m/e=344 (M+H)+.

Source