Reaction #433627

Reaction equation

sulfuric acid

chloroform methanol water

4-methoxybenzaldehyde

acetic acid

ethanol

→

6-methoxy-2-naphthylacetic acid

Conditions

Workup

1. 1
   Othercharred at 100° C.

Procedure

The final products, i.e. the phospholipid-drug conjugates obtained at the end of step 6, were subjected to TLC analysis under the following conditions: Silica gel 60 on aluminum sheet. Eluent is chloroform:methanol:water (65:35:5 v/v). Indicator is a spray of the composition: 4-methoxybenzaldehyde (10 ml), absolute ethanol (200 ml), 98% sulfuric acid (10 ml) and glacial acetic acid (2 ml). The chromatogram is sprayed with the indicator and then charred at 100° C.

Source