Reaction #433620

Reaction equation

sucrose

L-arginine

L-phenylalanine

→

Sucrose L-arginine L-phenylalanine

Conditions

Workup

1. 1
   workup.ADDITIONthe system was converted into a partially amorphous state by this addition
2. 2
   OtherThe products resulting
3. 3
   Otherafter drying

Procedure

Increasing amounts of L-arginine and L-phenylalanine in equal proportions (g/g) were added to a sucrose solution which contained 50 mg sucrose and 0.1 mg polysorbate 80 per ml. The samples were prepared as in example 1, dried and analysed. With amounts of up to 10 mg of each amino acid completely crystalline products were obtained. Partially amorphous products with a glass transition could only be identified above 10 mg L-arginine and 10 mg L-phenylalanine per ml. In this example not only the drying property of a solution was improved by addition of amino acids but the system was converted into a partially amorphous state by this addition. Increasing amounts of amino acids were added to a sugar solution containing 50 mg sucrose and 0.1 mg polysorbate 80 per ml. The products resulting after drying had the water contents and glass transition temperatures stated here.

Source